0001104659-06-015064 Sample Contracts

FIRST AMENDMENT TO LEASE FC 40 LANDSDOWNE, INC. To MILLENNIUM PHARMACEUTICALS, INC. Cambridge, MA
Lease • March 8th, 2006 • Millennium Pharmaceuticals Inc • Pharmaceutical preparations

This First Amendment to Lease is entered into as of the 5th day of November, 2001 between FC 40 LANDSDOWNE, INC. (“Landlord”) and MILLENNIUM PHARMACEUTICALS, INC. (“Tenant”).

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Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. THIRD AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • March 8th, 2006 • Millennium Pharmaceuticals Inc • Pharmaceutical preparations

This Third Amendment to Collaboration and License Agreement (this “Third Amendment”) effective as of October 31, 2005 (the “Third Amendment Date”) is by and between Millennium Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 75 Sidney Street, Cambridge, Massachusetts 02139 (“Millennium”) and Aventis Pharmaceuticals Inc., a member of the sanofi-aventis Group and a corporation organized and existing under the laws of the State of Delaware and having its principal office at Route 202-206, P.O. Box 6800, Bridgewater, New Jersey 08807 (“Aventis”). All capitalized terms used in this Third Amendment and not otherwise defined in this Third Amendment have the meanings assigned them in the Collaboration Agreement (as that term is defined in the first recital paragraph, below).

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