0001104659-06-017274 Sample Contracts

COMMERCIAL MANUFACTURING AGREEMENT
Commercial Manufacturing Agreement • March 16th, 2006 • Collagenex Pharmaceuticals Inc • Pharmaceutical preparations • New Jersey

This Commercial Manufacturing Agreement (“Agreement”) is made this 30th day of December, 2005, by and between Cardinal Health PTS, LLC, having a place of business at 14 Schoolhouse Road, Somerset, NJ 08873 (“Cardinal Health”) and CollaGenex Pharmaceuticals, Inc. (“Client”), having its principal place of business at 41 University Drive, Suite 200, Newtown, PA 18940.

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Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. AMENDMENT TO LICENSE AGREEMENT
License Agreement • March 16th, 2006 • Collagenex Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment is effective January 1, 2006 (the “Effective Date”), and amends that certain License Agreement dated August 24, 2001 (the “License”) by and between:

SHARE PURCHASE AGREEMENT
Share Purchase Agreement • March 16th, 2006 • Collagenex Pharmaceuticals Inc • Pharmaceutical preparations • Pennsylvania

SansRosa Pharmaceutical Development, Inc. (“SansRosa”), a corporation established under the laws of Delaware, with offices at One Tower Bridge, Suite 1350, 100 Front Street, West Conshohocken, PA 19428 (“SansRosa”),

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