0001104659-06-017401 Sample Contracts

SECOND AMENDMENT TO LEASE
Lease • March 16th, 2006 • Avant Immunotherapeutics Inc • In vitro & in vivo diagnostic substances • Massachusetts

This SECOND AMENDMENT TO LEASE (this “Amendment”) is made as of the 4th day of November, 2005, (the “Effective Date”) by and between MASSACHUSETTS DEVELOPMENT FINANCE AGENCY, a body politic and corporate and a public instrumentality of the Commonwealth of Massachusetts pursuant to Massachusetts General Laws, Chapter 23G, with an address of 160 Federal Street, Boston, Massachusetts 02110 (“Landlord”) and AVANT IMMUNOTHERAPEUTICS, INC., a Delaware corporation, with an address of 119 Fourth Avenue, Needham, Massachusetts (“Tenant”).

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FIRST AMENDMENT TO LEASE
Lease • March 16th, 2006 • Avant Immunotherapeutics Inc • In vitro & in vivo diagnostic substances • Massachusetts

Premises and completion of which after Tenant is in occupancy of the Premises will not unreasonably interfere with Tenant’s operations therein.

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