0001104659-06-039926 Sample Contracts

FIFTH LOAN MODIFICATION AGREEMENT
Fifth Loan Modification Agreement • June 6th, 2006 • Collagenex Pharmaceuticals Inc • Pharmaceutical preparations

This Fifth Loan Modification Agreement (this “Loan Modification Agreement”) is entered into as of May 31, 2006, by and between SILICON VALLEY BANK, a California-chartered bank, with its principal place of business at 3003 Tasman Drive, Santa Clara, California 95054 and with a loan production office located at One Newton Executive Park, Suite 200, 2221 Washington Street, Newton, Massachusetts 02462, doing business under the name “Silicon Valley East” (“Bank”) and COLLAGENEX PHARMACEUTICALS, INC., a Delaware corporation with its chief executive office located at 41 University Drive, Newtown, Pennsylvania 18940 (“Borrower”).

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