0001104659-06-073182 Sample Contracts

FIRST AMENDMENT
Lease Agreement • November 9th, 2006 • Cypress Bioscience Inc • Biological products, (no disgnostic substances)

THIS FIRST AMENDMENT (the “Amendment”) is made and entered into as of September 6, 2006, by and between CA-PARK PLAZA LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and CYPRESS BIOSCIENCE, INC., a Delaware corporation (“Tenant”).

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