0001104659-06-080509 Sample Contracts

UNDERWRITING AGREEMENT
Underwriting Agreement • December 8th, 2006 • Arena Pharmaceuticals Inc • Pharmaceutical preparations • New York

The undersigned, a holder of common stock (“Common Stock”) or rights to acquire Common Stock, of Arena Pharmaceuticals, Inc. (the “Company”) understands that the Company intends to file a Prospectus Supplement to the Prospectus dated September 12, 2006 pursuant to and in accordance with Rule 424(b) under the Securities Act of 1933, as amended, with the Securities and Exchange Commission on or about November 29, 2006 for the public offering of Common Stock (the “Offering”). The undersigned further understands that you, as Representative of the Underwriters, are contemplating entering into an underwriting agreement with the Company in connection with the Offering (the “Underwriting Agreement”). Capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Underwriting Agreement.

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