0001104659-07-003725 Sample Contracts

COMBINATORX, INCORPORATED 2004 Incentive Plan Amended and Restated Restricted Stock Award Agreement
Combinatorx, Inc • January 22nd, 2007 • Pharmaceutical preparations

The undersigned (i) acknowledges that on January 26, 2006, he received an award (the “Award”) of restricted stock from CombinatoRx, Incorporated (the “Company”) under the 2004 Incentive Plan (the “Plan”), (ii) hereby agrees to amend the terms of such award, subject to the terms set forth below and in the Plan; (iii) further acknowledges receipt of a copy of the Plan as in effect on the date hereof; and (iv) agrees with the Company as follows:

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COMBINATORX, INCORPORATED 2004 Incentive Plan Amended and Restated Restricted Stock Award Agreement
Restricted Stock Award Agreement • January 22nd, 2007 • Combinatorx, Inc • Pharmaceutical preparations

The undersigned (i) acknowledges that on January 26, 2006, he received an award (the “Award”) of restricted stock from CombinatoRx, Incorporated (the “Company”) under the 2004 Incentive Plan (the “Plan”), (ii) hereby agrees to amend the terms of such award, subject to the terms set forth below and in the Plan; (iii) further acknowledges receipt of a copy of the Plan as in effect on the date hereof; and (iv) agrees with the Company as follows:

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