0001104659-07-004281 Sample Contracts

PURCHASE AGREEMENT
Purchase Agreement • January 24th, 2007 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
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REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • January 24th, 2007 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York

REGISTRATION RIGHTS AGREEMENT, dated as of January 23, 2007, by and among Isis Pharmaceuticals, Inc. (together with any successor entity, herein referred to as the “Issuer”), and Lehman Brothers Inc., as representative (the “Representative”) of the initial purchasers attached hereto on Schedule I (collectively, the “Initial Purchasers”).

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