0001104659-07-071704 Sample Contracts

RETENTION AGREEMENT
Retention Agreement • September 27th, 2007 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • California

This RETENTION AGREEMENT (“Agreement”) is made and entered into by and between Mark K. Wedel (“Dr. Wedel”) and Isis Pharmaceuticals, Inc. (“Isis”) as of the Execution Date of this Agreement, September 21, 2007, and will be effective as of the Effective Date defined in Section 9 below.

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