0001104659-07-090488 Sample Contracts

FOR IMMEDIATE RELEASE BIOSPHERE MEDICAL AND DUPONT APPLIED BIOSCIENCES SIGN STRATEGIC COLLABORATION AGREEMENT
Strategic Collaboration Agreement • December 21st, 2007 • Biosphere Medical Inc • Surgical & medical instruments & apparatus

ROCKLAND, MA – December 20, 2007 – BioSphere Medical, Inc. (NASDAQ: BSMD) (“BioSphere”), a medical device company that has pioneered the use of bioengineered microspheres to treat uterine fibroids, hypervascularized tumors, and vascular malformations by a minimally invasive, image-guided medical procedure called embolotherapy, today announced that it has signed a strategic collaboration agreement with DuPont Applied BioSciences (DuPont) under which the companies intend to evaluate potential peripheral vascular and embolotherapy research, development, and manufacturing engineering projects.

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