0001104659-07-090873 Sample Contracts

AMENDED & RESTATED PROMISSORY NOTE
Promissory Note • December 26th, 2007 • Advanced Life Sciences Holdings, Inc. • Biological products, (no disgnostic substances) • Illinois

THIS AMENDED AND RESTATED PROMISSORY NOTE (this “Amended Note”) made effective as of the 21st day of December 2007 (the “Effective Date”), by and between Advanced Life Sciences, Inc., an Illinois corporation (the “Maker”), and Michael T. Flavin, Ph.D. (the “Payee”).

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