0001104659-08-029420 Sample Contracts

Re: License and Collaboration Agreement dated as of June 22, 2005 (the “Collaboration Agreement”) between Merck & Co., Inc. (“Merck”) and Metabasis Therapeutics, Inc. (“Metabasis”)
Metabasis Therapeutics Inc • May 2nd, 2008 • Pharmaceutical preparations

This Letter (this “Letter”) confirms the understanding of Merck and Metabasis regarding certain matters relating to the Collaboration Agreement and is intended to be legally binding on both parties. Capitalized terms used but not otherwise defined in this Letter shall have the meanings provided in the Collaboration Agreement. The parties agree to extend the Research Term, which is currently scheduled to terminate on June 21, 2008, on the terms and conditions specified in this Letter.

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