0001104659-08-043108 Sample Contracts

WARRANT TO PURCHASE SHARES OF COMMON STOCK
Helicos Biosciences Corp • June 30th, 2008 • Pharmaceutical preparations • New York

THIS CERTIFIES THAT, for value received, [GE Capital Equity Investments, Inc.] [CIT Healthcare LLC] (“Holder”) is entitled to subscribe for and purchase ( ) shares of fully paid and nonassessable Common Stock of Helicos Biosciences Corporation, a Delaware corporation (the “Company”), at the Warrant Price (as hereinafter defined), subject to the provisions and upon the terms and conditions hereinafter set forth. As used herein, the term “Common Stock” shall mean Company’s presently authorized common stock, $ par value per share, and any stock into which such common stock may hereafter be converted or exchanged and the term “Warrant Shares” shall mean the shares of Common Stock which Holder may acquire pursuant to this Warrant and any other shares of stock into which such shares of Common Stock may hereafter be converted or exchanged.

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SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • June 30th, 2008 • Helicos Biosciences Corp • Pharmaceutical preparations • New York

THIS SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is dated as of June 27, 2008 (the “Amendment Date”), by and among HELICOS BIOSCIENCES CORPORATION, a Delaware corporation (“Borrower”), GENERAL ELECTRIC CAPITAL CORPORATION, a Delaware corporation acting in its capacity as agent (the “Agent”) for the lenders under the Loan Agreement (as defined below) (the “Lenders”), and the Lenders.

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