0001104659-08-048933 Sample Contracts

Addendum to September 19, 2002
Promotion Agreement • July 31st, 2008 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations • New York

This Addendum to the U.S. Co-Promotion Agreement (the “Addendum”) is made effective as of the 8th day of May, 2008 (the “Effective Date”) by and between Amylin Pharmaceuticals, Inc. (“Amylin”), a Delaware corporation having its principal place of business at 9360 Towne Center Drive, San Diego, California, 92121.

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THIRD AMENDMENT TO SUPPLY AGREEMENT
Supply Agreement • July 31st, 2008 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations

THIS THIRD AMENDMENT to the Supply Agreement originally made and entered into as of October 1, 2003, by and between Amylin Pharmaceuticals, Inc. (“AMYLIN”) and Mallinckrodt Inc. (“MALLINCKRODT”), as amended effective on and as of January 1, 2006 and February 12, 2007, is made and entered into between AMYLIN and MALLINCKRODT effective on and as of January 1, 2008.

CONSULTING AGREEMENT
Consulting Agreement • July 31st, 2008 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations • California

The following contains all the items of an at-will consulting agreement between AMYLIN PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), located at 9360 Towne Centre Drive, San Diego, California 92121, and Alain Baron (“Consultant”), an individual located at 12863 Baywind Point, San Diego, CA 92130, effective as of June 1, 2008 (the “Effective Date”).

Amylin Pharmaceuticals, Inc. letterhead]
Amylin Pharmaceuticals Inc • July 31st, 2008 • Pharmaceutical preparations
AMENDED AND RESTATED COMMERCIAL SUPPLY AGREEMENT
Commercial Supply Agreement • July 31st, 2008 • Amylin Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS AMENDED AND RESTATED COMMERCIAL SUPPLY AGREEMENT (the “Agreement”) is entered into as of April 1, 2008 (the “Effective Date”), by and between AMYLIN PHARMACEUTICALS, INC. (“Company”), having its principal place of business located at 9360 Towne Centre Drive, San Diego, CA 92121, U.S.A. and Wockhardt UK (Holdings) Ltd., formerly CP Pharmaceuticals Ltd., (“Manufacturer”), having its registered office at Ash Road North, Wrexham Industrial Estate, Wrexham LL13 9UF, United Kingdom and as of the Effective Date hereof shall amend and replace in its entirety the Commercial Supply Agreement entered into between Company and Manufacturer as of October 7, 2004 (the “Commercial Supply Agreement”), as amended.

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