0001104659-08-069697 Sample Contracts

MANUFACTURING AGREEMENT
Manufacturing Agreement • November 10th, 2008 • Osiris Therapeutics, Inc. • Biological products, (no disgnostic substances) • Delaware

THIS MANUFACTURING AGREEMENT (the “Agreement”) is made and entered into as of July 24, 2008 (the “Effective Date”), by and between Osiris Therapeutics, Inc. (“Osiris”), a Delaware corporation, and NuVasive, Inc. (“NuVasive”), a Delaware corporation.

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AMENDMENT TO ASSET PURCHASE AGREEMENT
Asset Purchase Agreement • November 10th, 2008 • Osiris Therapeutics, Inc. • Biological products, (no disgnostic substances) • Delaware

This AMENDMENT TO ASSET PURCHASE AGREEMENT (this “Amendment”) dated as of September 30, 2008, is by and between OSIRIS THERAPEUTICS, INC. , a Delaware corporation (“ Seller ”), and NUVASIVE, INC. , a Delaware corporation (“ Purchaser ”). Capitalized terms used herein and not otherwise defined shall have the meaning given them in the Asset Purchase Agreement, dated May 8, 2008, between Seller and Purchaser (the “ Agreement ”). Seller and Purchaser shall each be referred to herein as a “ Party ” and collectively as the “ Parties ..”

AMENDMENT TO MANUFACTURING AGREEMENT
Manufacturing Agreement • November 10th, 2008 • Osiris Therapeutics, Inc. • Biological products, (no disgnostic substances)

THIS AMENDMENT TO MANUFACTURING AGREEMENT (“Amendment”) is made and entered into as of September 30, 2008 (the “ Effective Date “), by and between Osiris Therapeutics, Inc., a Delaware corporation (“ Osiris “), and NuVasive, Inc., a Delaware corporation (“ NuVasive “):

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