0001104659-08-069752 Sample Contracts

COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • November 10th, 2008 • Metabasis Therapeutics Inc • Pharmaceutical preparations • Delaware
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AMENDMENT AGREEMENT
Amendment Agreement • November 10th, 2008 • Metabasis Therapeutics Inc • Pharmaceutical preparations • New York

This Amendment Agreement (the “Amendment Agreement”) is effective as of the latest date of signature appearing below (the “Effective Date”) by and between Valeant Pharmaceuticals North America, a Delaware corporation and successor in interest to Valeant Research & Development, (“Valeant”), Metabasis Therapeutics, Inc., a Delaware corporation (“Metabasis”), and Schering Corporation, a New Jersey corporation (“Schering”). (Valeant, Metabasis, and Schering are each from time to time referred to individually as a “Party” and collectively as the “Parties”.)

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