0001104659-08-077897 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 22nd, 2008 • Helicos Biosciences Corp • Pharmaceutical preparations

This Registration Rights Agreement (this “Agreement”) is made and entered into as of December 19, 2008, by and among Helicos BioSciences Corporation, a Delaware corporation (the “Company”), and the several purchasers signatory hereto (each a “Purchaser” and collectively, the “Purchasers”).

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SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • December 22nd, 2008 • Helicos Biosciences Corp • Pharmaceutical preparations • Delaware

This Securities Purchase Agreement (this “Agreement”) is dated as of December 19, 2008, by and among Helicos BioSciences Corporation, a Delaware corporation (the “Company”), and the several purchasers identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

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