0001104659-09-031329 Sample Contracts

AMENDMENT NO. 3 TO MANUFACTURING AGREEMENT
Manufacturing Agreement • May 11th, 2009 • Osiris Therapeutics, Inc. • Biological products, (no disgnostic substances)

THIS AMENDMENT NO. 3 TO MANUFACTURING AGREEMENT (this “Third Amendment”) is made and entered into as of March 25, 2009 (the “Effective Date”), by and between Osiris Therapeutics, Inc., a Delaware corporation (“Osiris”), and NuVasive, Inc., a Delaware corporation (“NuVasive”).

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SUPPLY AGREEMENT
Supply Agreement • May 11th, 2009 • Osiris Therapeutics, Inc. • Biological products, (no disgnostic substances) • Delaware

This SUPPLY AGREEMENT (this “Agreement”) dated as of March 25, 2009, (“Effective Date”) is by and between OSIRIS THERAPEUTICS, INC., a Delaware corporation (“Osiris”), and ALLOSOURCE, an Illinois not-for-profit corporation (“AlloSource”) (any of which may be individually referred to herein as a “Party” and collectively as the “Parties”).

AMENDMENT NO. 2 TO ASSET PURCHASE AGREEMENT
Asset Purchase Agreement • May 11th, 2009 • Osiris Therapeutics, Inc. • Biological products, (no disgnostic substances) • Delaware

This AMENDMENT NO. 2 TO ASSET PURCHASE AGREEMENT (this “Second Amendment”), dated as of March 25, 2009, is by and between OSIRIS THERAPEUTICS, INC., a Delaware corporation (“Seller”), and NUVASIVE, INC., a Delaware corporation (“Purchaser”). Capitalized terms used herein and not otherwise defined shall have the meaning given them in that certain Asset Purchase Agreement by and between Seller and Purchaser dated May 8, 2008, as amended pursuant to that certain Amendment to Asset Purchase Agreement by and between Seller and Purchaser dated September 30, 2008 (collectively, the “Agreement”). Seller and Purchaser shall each be referred to herein as a “Party” and collectively as the “Parties.”

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