0001104659-09-070488 Sample Contracts

Underwriting Agreement
Underwriting Agreement • December 18th, 2009 • Helicos Biosciences Corp • Pharmaceutical preparations • New York

Helicos BioSciences Corporation, a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell to the Underwriter named in Schedule I hereto (the “Underwriter”) an aggregate of 6,400,000 units (the “Units”), with each Unit consisting of (i) one share of the common stock, par value $0.001 per share, of the Company (the “Common Stock”), and (ii) one warrant to purchase 0.65 shares of Common Stock (the “Warrants”). Units will not be issued or certificated. The shares of Common Stock to be issued in the offering contemplated hereby (the “Shares”) and the Warrants are immediately separable and will be issued separately. The terms and conditions of the Warrants are set forth in the form of Exhibit A attached hereto.

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