0001104659-09-072181 Sample Contracts

Contract
Second Supplemental Indenture • December 31st, 2009 • Celldex Therapeutics, Inc. • In vitro & in vivo diagnostic substances • New York

THIS SECOND SUPPLEMENTAL INDENTURE, dated as of December 31, 2009 (this “Second Supplemental Indenture”), is by and among CuraGen Corporation (the “CuraGen”), Celldex Therapeutics, Inc. (“Celldex”) and The Bank of New York Mellon (formerly, The Bank of New York), as trustee under the indenture referred to below (the “Trustee”).

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