0001104659-10-056160 Sample Contracts

FIRST AMENDMENT TO COLLABORATION RESEARCH AND LICENSE AGREEMENT

Collaboration Research and License Agreement • November 5th, 2010 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

• Contract Type
  Collaboration Research and License Agreement
• Filed
  November 5th, 2010
• Company
  Isis Pharmaceuticals Inc
• Industry
  Pharmaceutical preparations

THIS FIRST AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT (the “Amendment”) is made and entered into effective as of July 27, 2010 (the “First Amendment Effective Date”) by and between Bristol-Myers Squibb Company, a Delaware corporation (“BMS”) and Isis Pharmaceuticals, Inc., a Delaware Corporation (“Isis”).