0001104659-11-002362 Sample Contracts

INVESTMENT AGREEMENT
Investment Agreement • January 21st, 2011 • Advanced Life Sciences Holdings, Inc. • Biological products, (no disgnostic substances) • Massachusetts

Pursuant to the Put given by Advanced Life Sciences Holdings, Inc. to Dutchess Opportunity Fund, II, LP on 200 , we are now submitting the amount of common shares for you to issue to Dutchess.

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REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • January 21st, 2011 • Advanced Life Sciences Holdings, Inc. • Biological products, (no disgnostic substances) • Massachusetts

Registration Rights Agreement (the “Agreement”), dated as of December XX, 2010, by and between Advanced Life Sciences Holdings, Inc., a corporation organized under the laws of Delaware, USA (the “Company”), and Dutchess Opportunity Fund, II, LP, a Delaware Limited Partnership (the “Investor”).

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