0001104659-11-067195 Sample Contracts

FIRST AMENDMENT TO SUBORDINATED SECURED NOTE PURCHASE AGREEMENT
Subordinated Secured Note Purchase Agreement • December 1st, 2011 • Helicos Biosciences Corp • Pharmaceutical preparations

THIS FIRST AMENDMENT TO SUBORDINATED SECURED NOTE PURCHASE AGREEMENT (the “First Amendment”) is made this 30th day of November, 2011 (the “Effective Date”), by and among HELICOS BIOSCIENCES CORPORATION, a Delaware corporation (the “Company”), and each of the purchasers named on the Schedule of Purchasers attached hereto as Schedule 1 (the “Schedule of Purchasers”) as a “Purchaser” (each individually a “Purchaser,” and collectively the “Purchasers”).

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