0001104659-12-043602 Sample Contracts

THE MEDICINES COMPANY AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of June 11, 2012 1.375% Convertible Senior Notes due 2017
Indenture • June 14th, 2012 • Medicines Co /De • Pharmaceutical preparations • New York

INDENTURE dated as of June 11, 2012 between THE MEDICINES COMPANY, a Delaware corporation, as issuer (the “Company”, as more fully set forth in Section 1.01) and WELLS FARGO BANK, NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee”, as more fully set forth in Section 1.01).

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