0001104659-12-054145 Sample Contracts

April 6, 2012 John Prunty c/o Optimer Pharmaceuticals, Inc. San Diego, CA 92121 Re: Separation from Optimer Pharmaceuticals, Inc. Dear John:
Separation Agreement • August 3rd, 2012 • Optimer Pharmaceuticals Inc • Pharmaceutical preparations

This letter sets forth the terms and conditions of our agreement (the “Agreement”) regarding the termination of your employment with OPTIMER PHARMACEUTICALS, INC. (the “Company”). This Agreement shall be effective as of the Effective Date as defined in Section 12(d) herein. As part of this Agreement, and pursuant to and subject to the terms of the Company’s Amended and Restated Severance Benefit Plan (the “Severance Plan”), the Company will provide you the Regular Covered Termination Severance Benefits outlined below (the “Severance Benefits”). All initially capitalized terms not otherwise defined herein shall have the meaning ascribed to such terms in the Severance Plan.

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AMENDMENT TO API MANUFACTURING AND SUPPLY AGREEMENT
Api Manufacturing and Supply Agreement • August 3rd, 2012 • Optimer Pharmaceuticals Inc • Pharmaceutical preparations

This AMENDMENT TO MANUFACTURING AND SUPPLY AGREEMENT (this “Amendment”), is entered into as of May 20, 2011 by and between OPTIMER PHARMACEUTICALS, INC. (“Optimer”) and BIOCON LIMITED (“Biocon”). Capitalized terms used herein which are not defined herein shall have the definitions ascribed to them in the Agreement (defined below).

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