0001104659-12-057327 Sample Contracts

ISIS PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of August 13, 2012 2.75% Convertible Senior Notes due 2019
Indenture • August 13th, 2012 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York

INDENTURE dated as of August 13, 2012 between Isis Pharmaceuticals, Inc., a Delaware corporation, as issuer (the “Company”, as more fully set forth in Section 1.01) and Wells Fargo Bank, National Association, a national banking association, as trustee (the “Trustee”, as more fully set forth in Section 1.01).

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