0001104659-12-065620 Sample Contracts

THIRD LOAN MODIFICATION AGREEMENT
Third Loan Modification Agreement • September 26th, 2012 • Nupathe Inc. • Pharmaceutical preparations • Maryland

This Third Loan Modification Agreement (this “Loan Modification Agreement”) is entered into as of September 25, 2012 by and among (i) MIDCAP FUNDING III, LLC, a Delaware limited liability company with an office located at 7255 Woodmont Avenue, Suite 200, Bethesda, Maryland 20814 (“MidCap”), as collateral agent (“Agent”); (ii) MidCap as a “Lender”; (iii) SILICON VALLEY BANK, a California corporation with a loan production office located at 100 Matsonford Road, Building 5, Suite 555, Radnor, Pennsylvania 19087 (“SVB”), as a “Lender” (MidCap and SVB in their capacities as a “Lender” are each referred to herein as a “Lender”, and are collectively referred to herein as the “Lenders”); and (iv) NUPATHE INC., a Delaware corporation (“Borrower”).

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