0001104659-12-073679 Sample Contracts

Dear Pedro Collaboration and License Agreement between Optimer Pharmaceuticals Inc and Astellas Pharma Europe Limited dated 2 February 2011 (the “Collaboration Agreement”) Amendment No 1
Collaboration and License Agreement • November 2nd, 2012 • Optimer Pharmaceuticals Inc • Pharmaceutical preparations

In accordance with Section 14.7 of the Collaboration Agreement we have agreed to amend the Collaboration Agreement as follows:

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THIRD AMENDMENT TO API MANUFACTURING AND SUPPLY AGREEMENT
Api Manufacturing and Supply Agreement • November 2nd, 2012 • Optimer Pharmaceuticals Inc • Pharmaceutical preparations

This Third Amendment (this “Third Amendment”) dated as of the 10th day of September, 2012 (the “Third Amendment Date”), is made by and between Biocon Limited (“Biocon”) and Optimer Pharmaceuticals, Inc. (“Optimer”).

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