0001104659-13-083295 Sample Contracts

September 20, 2013 John Poyhonen San Diego, CA 92130 Dear John:
Senomyx Inc • November 12th, 2013 • Services-commercial physical & biological research • California

This letter will reflect the terms of your ongoing employment with Senomyx, Inc. (the “Company”) following your promotion to the position of Chief Executive Officer of the Company following the retirement of Kent Snyder. Following your promotion, you will also continue to serve as the Company’s President. The following terms apply and will constitute your employment agreement with the Company (the “Agreement”).

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September 20, 2013 Kent Snyder Rancho Santa Fe, CA 92067 Dear Kent:
Senomyx Inc • November 12th, 2013 • Services-commercial physical & biological research • California

This letter (the “Agreement”) sets forth the terms of your voluntary retirement and resignation as Chief Executive Officer of Senomyx, Inc. (the “Company”) and your continuing service as Chairman of the Company’s Board of Directors.

SECOND AMENDMENT TO CHANGE IN CONTROL AGREEMENT
Change in Control Agreement • November 12th, 2013 • Senomyx Inc • Services-commercial physical & biological research • California

THIS SECOND AMENDMENT TO CHANGE IN CONTROL AGREEMENT (this “Amendment”) is made and entered into as of September 20, 2013, by and between SENOMYX, INC., a Delaware corporation (the “Company”), and John Poyhonen (the “Employee”).

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