0001104659-14-052248 Sample Contracts

SYNTA PHARMACEUTICALS CORP. Common Stock (par value $0.0001 per share) At the Market Issuance Sales Agreement
Common Stock • July 18th, 2014 • Synta Pharmaceuticals Corp • Pharmaceutical preparations • New York

Synta Pharmaceuticals Corp., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with MLV & Co. LLC, a Delaware limited liability company (“MLV”), as follows:

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TENTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • July 18th, 2014 • Synta Pharmaceuticals Corp • Pharmaceutical preparations • New York

THIS TENTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is dated as of July 17, 2014 and is effective as of the Amendment Effective Date (as defined in Section 6), by and among SYNTA PHARMACEUTICALS CORP., a Delaware corporation (“Borrower”), SYNTA SECURITIES CORP., a Massachusetts corporation (“Guarantor”; together with the Borrower, each a “Loan Party” and, collectively, the “Loan Parties”), GENERAL ELECTRIC CAPITAL CORPORATION, a Delaware corporation, acting in its capacity as agent (“Agent”) for the lenders under the Loan Agreement (as defined below) (“Lenders”), and the Lenders.

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