0001104659-14-079030 Sample Contracts

ONE EXETER PLAZA BOSTON, MASSACHUSETTS (THE “BUILDING”) FIRST AMENDMENT MAY 15, 2014
EPIRUS Biopharmaceuticals, Inc. • November 10th, 2014 • Pharmaceutical preparations

LANDLORD: CPT One Exeter Plaza, LLC, a Delaware limited liability company with a principal place of business c/o AEW Capital Management, L.P., Two Seaport Lane, World Trade Center East, Boston, MA 02210

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AMENDMENT No. 1 to RANBAXY — EPIRUS LICENSE AGREEMENT
EPIRUS Biopharmaceuticals, Inc. • November 10th, 2014 • Pharmaceutical preparations

This Amendment No. 1, dated as of 09 September, 2014 (the “Amendment Effective Date”), to the License Agreement (as defined below), by and between Epirus Switzerland GmbH, a Swiss corporation having its principal place of business at Alpenstrasse 15, 6304 Zug, Switzerland (“Epirus”) and Ranbaxy Laboratories Limited, an Indian company having its Registered Office at A-41, Industrial Area Phase VIII-A, Sahibzada Ajit Singh Nagar, Mohali - 160 071, Punjab, India, and its Corporate Office at Plot No. 90 Sector 32, Gurgaon — 122 001, Haryana, India (“Ranbaxy”).

Contract
Exclusive License and Collaboration Agreement • November 10th, 2014 • EPIRUS Biopharmaceuticals, Inc. • Pharmaceutical preparations • England and Wales

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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