0001104659-14-082750 Sample Contracts

ISIS PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of November 17, 2014 1.00% Convertible Senior Notes due 2021
Indenture • November 21st, 2014 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York

INDENTURE dated as of November 17, 2014 between Isis Pharmaceuticals, Inc., a Delaware corporation, as issuer (the “Company,” as more fully set forth in Section 1.01) and Wells Fargo Bank, National Association, a national banking association, as trustee (the “Trustee,” as more fully set forth in Section 1.01).

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