0001104659-16-100066 Sample Contracts

EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • February 25th, 2016 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) dated as of May 29, 2015 is made and entered into by and between Synergy Pharmaceuticals Inc., a company incorporated under the laws of the state of Delaware (the “Company”), and Troy M. Hamilton, an individual (the “Executive”).

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Contract
Employment Agreement • February 25th, 2016 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This AMENDMENT (the “Amendment”) to the AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) originally dated as of July 12, 2013, by and between Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”) and Patrick H. Griffin, M.D., FACP (the “Executive”) is dated as of January 18, 2016. Capitalized terms not defined herein shall have the meanings assigned to them in the Agreement.

EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • February 25th, 2016 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) dated as of November 10, 2015 is made and entered into by and between Synergy Pharmaceuticals Inc., a company incorporated under the laws of the state of Delaware (the “Company”), and Gary L. Sender, M.S., an individual (the “Executive”).

Contract
Employment Agreement • February 25th, 2016 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This AMENDMENT (the “Amendment”) to the EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) originally dated as of May 29, 2015, by and between Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”) and Troy M. Hamilton (the “Executive”) is dated as of January 18, 2016. Capitalized terms not defined herein shall have the meanings assigned to them in the Agreement.

Contract
Employment Agreement • February 25th, 2016 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This AMENDMENT (the “Amendment”) to the FOURTH AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) originally dated as of January 7, 2015, by and between Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”) and Gary S. Jacob, Ph.D. (the “Executive”) is dated as of January 18, 2016. Capitalized terms not defined herein shall have the meanings assigned to them in the Agreement.

AMENDMENT TO THIRD AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT
Employment Agreement • February 25th, 2016 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This AMENDMENT (the “Amendment”) to the THIRD AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) originally dated as of January 7, 2015, by and between Synergy Pharmaceuticals Inc., a Delaware corporation (the “Company”) and Kunwar Shailubhai (the “Executive”) is dated as of January 18, 2016. Capitalized terms not defined herein shall have the meanings assigned to them in the Agreement.

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