0001104659-16-163798 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 23rd, 2016 • Strongbridge Biopharma PLC • Pharmaceutical preparations

This Registration Rights Agreement (this “Agreement”) is made and entered into as of December 22, 2016, by and among Strongbridge Biopharma plc, an Irish public limited company (the “Company”), and the several purchasers signatory hereto (each a “Purchaser” and collectively, the “Purchasers”).

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ORDINARY SHARE PURCHASE WARRANT STRONGBRIDGE BIOPHARMA PLC
Security Agreement • December 23rd, 2016 • Strongbridge Biopharma PLC • Pharmaceutical preparations

THIS ORDINARY SHARE PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after June , 2017 (the “Initial Exercise Date”) and on or prior to the close of business on the five (5) year anniversary of the Initial Exercise Date (the “Termination Date”) but not thereafter, to subscribe for and purchase from Strongbridge Biopharma plc, an Irish public limited company (the “Company”), up to ordinary shares (as subject to adjustment hereunder, the “Warrant Shares”). The purchase price of one ordinary share under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • December 23rd, 2016 • Strongbridge Biopharma PLC • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of December 22, 2016 by and among Strongbridge Biopharma plc, an Irish public limited company (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

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