0001104659-17-028401 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • May 1st, 2017 • Motif Bio PLC • Pharmaceutical preparations

This Employment Agreement (this “Agreement”) is effective as of January 16, 2017 (the “Effective Date”), and is entered into by and between Motif BioSciences Inc. (the “Company”), and Robert Dickey IV (“Employee”) (collectively with the Company, the “Parties”; each of the Parties referred to individually as a “Party”).

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2,438,491 AMERICAN DEPOSITARY SHARES, EACH REPRESENTING 20 ORDINARY SHARES, £0.01 PAR VALUE, AND WARRANTS TO PURCHASE 1,219,246 AMERICAN DEPOSITARY SHARES MOTIF BIO PLC UNDERWRITING AGREEMENT
Underwriting Agreement • May 1st, 2017 • Motif Bio PLC • Pharmaceutical preparations • New York

This letter is delivered to you pursuant to the Underwriting Agreement (the “Underwriting Agreement”) to be entered into by the Company, as issuer, and Rodman & Renshaw, a unit of H.C. Wainwright & Co., LLC, as representative (the “Representative”) of certain underwriters (the “Underwriters”) to be named therein. Upon the terms and subject to the conditions of the Underwriting Agreement, the Underwriters intend to effect a public offering of American Depositary Shares (“ADSs”), each of which represents 20 Ordinary Shares, of one penny each in capital, of the Company (the “Ordinary Shares”), and warrants (“Warrants”) to purchase ADSs, as described in and contemplated by the registration statement of the Company on Form F-1, File No. 333-212491 (the “Registration Statement”), as subsequently amended (the “Offering”).

INDEPENDENT CONTRACTOR AGREEMENT
Independent Contractor Agreement • May 1st, 2017 • Motif Bio PLC • Pharmaceutical preparations • New York

This Independent Contractor Agreement (the “Agreement”) is entered into on this 7th day of April, 2017, between Motif BioSciences Inc. (“Motif”), and Jonathan E. Gold (“Consultant”), each a “Party” and, collectively, the “Parties.”

CONFIDENTIAL SEPARATION AGREEMENT AND RELEASE
Confidential Separation Agreement and Release • May 1st, 2017 • Motif Bio PLC • Pharmaceutical preparations • New York

THIS CONFIDENTIAL SEPARATION AGREEMENT AND RELEASE (the “Agreement”) is made and entered into by and between Pete A. Meyers (“Meyers”) and Motif BioSciences Inc., (the “Company”) (collectively, the “Parties”)

CONSULTING AGREEMENT Effective Date: January 16, 2017
Consulting Agreement • May 1st, 2017 • Motif Bio PLC • Pharmaceutical preparations • Delaware

THIS CONSULTING AGREEMENT (this “Agreement”) is entered into by and between Motif Biosciences, Inc., a Delaware corporation (the “Company”), and Pete A. Meyers, an individual (“Consultant”), as of the date set forth above (the “Effective Date”).

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