0001104659-17-032568 Sample Contracts

AMAG PHARMACEUTICALS, INC. AND WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of May 10, 2017 to Indenture Dated as of May 10, 2017 3.25% Convertible Senior Notes due 2022
First Supplemental Indenture • May 15th, 2017 • Amag Pharmaceuticals Inc. • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE dated as of May 10, 2017 (this “Supplemental Indenture”) between AMAG PHARMACEUTICALS, INC., a Delaware corporation, as issuer (the “Company,” as more fully set forth in Section 1.01) and WILMINGTON TRUST, NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee,” as more fully set forth in Section 1.01), supplementing the Indenture dated as of May 10, 2017 between the Company and the Trustee (the “Base Indenture” and the Base Indenture, as amended and supplemented by this Supplemental Indenture, and as it may be further amended or supplemented from time to time with respect to the Notes, the “Indenture”).

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