0001104659-18-000240 Sample Contracts

FIRST AMENDMENT TO NOTE PURCHASE AGREEMENT AND NOTES
Note Purchase Agreement • January 2nd, 2018 • Jaguar Health, Inc. • Pharmaceutical preparations • Delaware

This FIRST AMENDMENT TO NOTE PURCHASE AGREEMENT AND NOTES (this “Amendment”), dated as of December 29, 2017, by and among Napo Pharmaceuticals, Inc., a Delaware Corporation (“Napo” or the “Company”) and each party identified on the signature pages hereto as a purchaser of the Notes (as defined below) pursuant to the Note Purchase Agreement (as defined below) (collectively, the “Purchasers” and each, a “Purchaser”).

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