0001104659-18-004153 Sample Contracts

INSMED INCORPORATED AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee First Supplemental Indenture Dated as of January 26, 2018 to Indenture Dated as of January 26, 2018 1.75% Convertible Senior Notes due 2025
First Supplemental Indenture • January 26th, 2018 • INSMED Inc • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE dated as of January 26, 2018 (this “Supplemental Indenture”) between Insmed Incorporated, a Virginia corporation, as issuer (the “Company”, as more fully set forth in Section 1.01) and Wells Fargo Bank, National Association, a national banking association, as trustee (the “Trustee”, as more fully set forth in Section 1.01), supplementing the Indenture, dated as of January 26, 2018, between the Company and the Trustee (the “Base Indenture” and the Base Indenture, as amended and supplemented by this Supplemental Indenture, and as it may be further amended or supplemented from time to time with respect to the Notes, the “Indenture”).

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