0001104659-18-023117 Sample Contracts

REGISTRATION AGREEMENT
Registration Agreement • April 10th, 2018 • Motif Bio PLC • Pharmaceutical preparations • New York

THIS REGISTRATION AGREEMENT is entered into as of November 14, 2017 by and between Motif Bio Plc, a public limited company incorporated in England and Wales (the “Company”), and Hercules Capital, Inc., a Maryland corporation (“Hercules”).

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LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • April 10th, 2018 • Motif Bio PLC • Pharmaceutical preparations • California

THIS LOAN AND SECURITY AGREEMENT is made and dated as of November 14, 2017 and is entered into by and among MOTIF BIOSCIENCES INC., a Delaware corporation, and each of its Qualified Subsidiaries (hereinafter collectively referred to herein as the “Borrower”), the several banks and other financial institutions or entities from time to time parties to this Agreement (collectively, referred to herein as “Lender”) and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and the Lender (in such capacity, the “Agent”).

Contract
Warrant Agreement • April 10th, 2018 • Motif Bio PLC • Pharmaceutical preparations • New York

THIS WARRANT AND THE SHARES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR, SUBJECT TO SECTION 11 HEREOF, AN OPINION OF COUNSEL (WHICH MAY BE COMPANY COUNSEL) REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT, OR SUCH LAWS.

CONFIDENTIAL SEPARATION AGREEMENT AND RELEASE
Separation Agreement • April 10th, 2018 • Motif Bio PLC • Pharmaceutical preparations • New York

THIS CONFIDENTIAL SEPARATION AGREEMENT AND RELEASE (the “Agreement”) is made and entered into by and between Robert Dickey IV (“Dickey”) and Motif BioSciences, Inc. (the “Company”) (collectively, the “Parties”).

CONSULTING AGREEMENT Effective Date: February 2, 2018
Consulting Agreement • April 10th, 2018 • Motif Bio PLC • Pharmaceutical preparations • Delaware

THIS CONSULTING AGREEMENT (this “Agreement”) is entered into by and between Motif Biosciences, Inc., a Delaware corporation (the “Company”), and Robert Dickey IV, an individual (“Consultant”), as of the date set forth above (the “Effective Date”).

STOCK PLEDGE AGREEMENT
Stock Pledge Agreement • April 10th, 2018 • Motif Bio PLC • Pharmaceutical preparations • California

This Stock Pledge Agreement (this “Agreement”) is entered into as of November 14, 2017, by and between HERCULES CAPITAL, INC., as administrative agent and collateral agent (in such capacity, “Agent”) for a syndicate of secured parties (together with Agent, collectively, “Secured Parties”) and MOTIF BIO PLC, a public limited company organized under the laws of England and Wales (“Pledgor”).

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