0001104659-18-062543 Sample Contracts

VERASTEM, INC. and
Indenture • October 17th, 2018 • Verastem, Inc. • Pharmaceutical preparations • New York
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VERASTEM, INC. and WILMINGTON TRUST, NATIONAL ASSOCIATION as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of October 17, 2018 5.00% Convertible Senior Notes due 2048
Verastem, Inc. • October 17th, 2018 • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE, dated as of October 17, 2018 (“First Supplemental Indenture”), between Verastem, Inc., a Delaware corporation, as issuer (the “Company”), and Wilmington Trust, National Association, a national banking association, as trustee (the “Trustee”), supplementing the Indenture, dated as of October 17, 2018, between the Company and the Trustee (the “Base Indenture” and, as amended, modified and supplemented by this First Supplemental Indenture, the “Indenture”).

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