0001104659-19-003151 Sample Contracts

SECOND SUPPLEMENTAL INDENTURE
Second Supplemental Indenture • January 24th, 2019 • TESARO, Inc. • Pharmaceutical preparations • New York

THIS SECOND SUPPLEMENTAL INDENTURE (this “Second Supplemental Indenture”) dated as of January 22, 2019 between TESARO, INC. (the “Company”) and U.S. BANK NATIONAL ASSOCIATION, as trustee under the Indenture referred to below (the “Trustee”). All capitalized terms used but not otherwise defined herein shall have the respective meanings ascribed to such terms in the Indenture (as defined below).

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