0001104659-19-048256 Sample Contracts

Zynerba Pharmaceuticals, Inc. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement
Sales Agreement • August 30th, 2019 • Zynerba Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

Zynerba Pharmaceuticals, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co., Canaccord Genuity LLC, H.C. Wainwright & Co., LLC and Ladenburg Thalmann & Co. Inc. (each, an “Agent,” and collectively, the “Agents”), as follows:

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August 30, 2019 Armando Anido Dear Armando:
Zynerba Pharmaceuticals, Inc. • August 30th, 2019 • Pharmaceutical preparations

As you know, you and Zynerba Pharmaceuticals, Inc. (the “Company”) are parties to that certain employment agreement dated as of September 4, 2014 (as amended and/or restated from time to time, the “Employment Agreement”). For good and valuable consideration, you and the Company hereby agree to amend the Employment Agreement as follows:

August 30, 2019 Terri B. Sebree Dear Terri:
Zynerba Pharmaceuticals, Inc. • August 30th, 2019 • Pharmaceutical preparations

As you know, you and Zynerba Pharmaceuticals, Inc. (the “Company”) are parties to that certain employment agreement dated as of October 2, 2014 (as amended and/or restated from time to time, the “Employment Agreement”). For good and valuable consideration, you and the Company hereby agree to amend the Employment Agreement as follows:

August 30, 2019 James E. Fickenscher East, Teleford, PA 18969 Dear Jim:
Zynerba Pharmaceuticals, Inc. • August 30th, 2019 • Pharmaceutical preparations

As you know, you and Zynerba Pharmaceuticals, Inc. (the “Company”) are parties to that certain employment agreement dated as of August 11, 2016 (as amended and/or restated from time to time, the “Employment Agreement”). For good and valuable consideration, you and the Company hereby agree to amend the Employment Agreement as follows:

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