0001104659-19-075690 Sample Contracts

26,982,945 Shares of Common Stock and Pre-Funded Warrants to Purchase 9,017,055 Shares of Common Stock Abeona Therapeutics Inc. UNDERWRITING AGREEMENT
Underwriting Agreement • December 23rd, 2019 • Abeona Therapeutics Inc. • Pharmaceutical preparations • New York
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Abeona Therapeutics Inc. 1330 Avenue of the Americas, 33rd Floor New York, NY 10019 December 20, 2019
Letter Agreement Regarding Certain Purchaser Rights • December 23rd, 2019 • Abeona Therapeutics Inc. • Pharmaceutical preparations • New York

Abeona Therapeutics Inc., a Delaware corporation (the “Company”), is contemplating an offering of shares of common stock, par value $0.01 per share (“Common Stock”), and warrants to purchase shares of Common Stock as described in the Company’s Prospectus Supplement, dated December [20], 2019, to the Prospectus dated June 7, 2018 (the “Offering”). In consideration for Biomedical Value Fund, L.P., Biomedical Offshore Value Fund, Ltd. and GEF-SMA, L.P. (collectively, “Purchaser”) purchasing in the aggregate at least $31 million in Common Stock and/or warrants in the Offering, the Company and Purchaser agree as follows:

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