0001104659-20-003271 Sample Contracts

UNDERWRITING AGREEMENT APTINYX INC. 10,166,666 Shares of Common Stock, par value $0.01 per share January 10, 2020
Underwriting Agreement • January 13th, 2020 • Aptinyx Inc. • Pharmaceutical preparations • New York

Aptinyx Inc., a Delaware corporation (the “Company”), proposes to issue and sell to the several underwriters listed in Schedule 1 hereto (the “Underwriters”), for whom you are acting as representative (the “Representative”), an aggregate of 10,166,666 shares of common stock, par value $0.01 per share (the “Common Stock”), of the Company (the “Underwritten Shares”) and, at the option of the Underwriters, up to an additional 1,525,000 shares of Common Stock, of the Company (the “Option Shares”). The Underwritten Shares and the Option Shares are herein referred to as the “Shares.” The shares of Common Stock of the Company to be outstanding after giving effect to the sale of the Shares are referred to herein as the “Stock.”

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