0001104659-21-133381 Sample Contracts

October 28, 2021 Modified November 1, 2021 VIA EMAIL Derek Chalmers Re: Separation Agreement Dear Derek:
Separation Agreement • November 3rd, 2021 • Cara Therapeutics, Inc. • Pharmaceutical preparations • Connecticut

We have mutually agreed that you will transition as CEO and this letter sets forth the substance of the Separation Agreement (the “Separation Agreement” or “Agreement”) which Cara Therapeutics, Inc. (the “Company”) is offering to aid in your employment transition. You may review and comment on the press release regarding the transition.

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EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • November 3rd, 2021 • Cara Therapeutics, Inc. • Pharmaceutical preparations • Connecticut

This Executive Employment Agreement (the “Agreement”) is entered into effective October 29, 2021 (the “Effective Date”), by and between Chris Posner (“Executive”) and Cara Therapeutics, Inc. (the “Company”).

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