UNDERWRITING AGREEMENT between AVENUE THERAPEUTICS, INC. and AEGIS CAPITAL CORP., as Representative of the Several Underwriters AVENUE THERAPEUTICS, INC. UNDERWRITING AGREEMENTUnderwriting Agreement • December 13th, 2021 • Avenue Therapeutics, Inc. • Pharmaceutical preparations • New York
Contract Type FiledDecember 13th, 2021 Company Industry JurisdictionThe undersigned, Avenue Therapeutics, Inc., a corporation formed under the laws of the State of Delaware (collectively with its subsidiaries and affiliates, including, without limitation, all entities disclosed or described in the Registration Statement (as hereinafter defined) as being subsidiaries or affiliates of Avenue Therapeutics, Inc., the “Company”), hereby confirms its agreement (this “Agreement”) with Aegis Capital Corp. (hereinafter referred to as “you” (including its correlatives) or the “Representative”) and with the other underwriters named on Schedule 1 hereto for which the Representative is acting as representative (the Representative and such other underwriters being collectively called the “Underwriters” or, individually, an “Underwriter”) as follows: