0001104659-21-153200 Sample Contracts

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • December 23rd, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations

This First Amendment to Employment Agreement (this “First Amendment”) is entered into as of December 22, 2021 (the “Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Chris Murray (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

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SECOND AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • December 23rd, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations

This Second Amendment to Employment Agreement (this “Second Amendment”) is entered into as of December 22, 2021 (the “Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Debra Durso-Bumpus (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

FIRST AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • December 23rd, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations

This First Amendment to Employment Agreement (this “First Amendment”) is entered into as of December 22, 2021 (the “Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Percy H. Carter, Ph. D., MBA (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

FIRST AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • December 23rd, 2021 • Blueprint Medicines Corp • Pharmaceutical preparations

This First Amendment to Amended and Restated Employment Agreement (this “First Amendment”) is entered into as of December 22, 2021 (the “Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and L. Becker Hewes, M.D. (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

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