0001104659-22-037319 Sample Contracts

AMENDMENT NO. 1 TO SALES AGREEMENT
Sales Agreement • March 24th, 2022 • Aptinyx Inc. • Pharmaceutical preparations • New York

Aptinyx Inc., a Delaware corporation (the “Company”), together with Cowen and Company, LLC (the “Agent”), are parties to that certain Sales Agreement dated September 16, 2021 (the “Original Agreement”). All capitalized terms not defined herein shall have the meanings ascribed to them in the Original Agreement. The Company and the Agent desire to amend the Original Agreement as set forth in this Amendment No. 1 thereto (this “Amendment”) as follows:

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