0001104659-22-102734 Sample Contracts

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This Second Amendment to Employment Agreement (this “Second Amendment”) is dated as of September 23, 2022 (the “Second Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Ariel Hurley (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

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FIRST AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This First Amendment to Amended and Restated Employment Agreement (the “First Amendment”) is dated as of September 23, 2022 (the “First Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Christina Rossi (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This Second Amendment to Employment Agreement (this “Second Amendment”) is dated as of September 23, 2022 (the “Second Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Percy Carter Ph. D., MBA (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This Second Amendment to Employment Agreement (this “Second Amendment”) is dated as of September 23, 2022 (the “Second Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Chris Murray (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

THIRD AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This Third Amendment to Employment Agreement (this “Third Amendment”) is dated as of September 23, 2022 (the “Third Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Debra Durso-Bumpus (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

THIRD AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This Third Amendment to Employment Agreement (this “Third Amendment”) is dated as of September 23, 2022 (the “Third Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Michael Landsittel (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

SECOND AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This Second Amendment to Amended and Restated Employment Agreement (this “Second Amendment”) is dated as of September 23, 2022 (the “Second Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and L. Becker Hewes, M.D. (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

FIRST AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • September 23rd, 2022 • Blueprint Medicines Corp • Pharmaceutical preparations

This First Amendment to Amended and Restated Employment Agreement (this “First Amendment”) is dated as of September 23, 2022 (the “First Amendment Effective Date”), between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Kathryn Haviland (the “Executive”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

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