0001104659-23-026247 Sample Contracts

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • February 28th, 2023 • Quoin Pharmaceuticals, Ltd. • Surgical & medical instruments & apparatus • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of February 22, 2023, between Quoin Pharmaceuticals Ltd., a company organized under the laws of Israel (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

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PRE-FUNDED warrant To purchase ordinary shares represented by american depositary shares Quoin Pharmaceuticals Ltd.
Pre-Funded Warrant Agreement • February 28th, 2023 • Quoin Pharmaceuticals, Ltd. • Surgical & medical instruments & apparatus

THIS PRE-FUNDED WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, [_____________] or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from QUOIN PHARMACEUTICALS LTD., a corporation incorporated under the laws of Israel (the “Company”), up to [●] ordinary shares, no par value per share (the “Ordinary Shares”), of the Company (as subject to adjustment hereunder, the “Warrant Shares”) represented by [●] American Depositary Shares of the Company (“ADSs,” and the ADSs issuable hereunder, the “Warrant ADSs”), with each ADS representing five thousand (5,000) Ordinary Shares (the “ADS Ratio”). The purchase price of one Warrant ADS under this Wa

WARRANT to purchase ordinary shares represented by american depositary shares Quoin Pharmaceuticals Ltd.
Warrant Agreement • February 28th, 2023 • Quoin Pharmaceuticals, Ltd. • Surgical & medical instruments & apparatus

THIS WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (the “Warrant”) certifies that, for value received, [_____________] or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after February 24, 2023 (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on February 24, 2028 (the “Termination Date”) but not thereafter, to subscribe for and purchase from QUOIN PHARMACEUTICALS LTD., a corporation incorporated under the laws of Israel (the “Company”), up to [●] ordinary shares, no par value per share (the “Ordinary Shares”), of the Company (as subject to adjustment hereunder, the “Warrant Shares”) represented by [●] American Depositary Shares of the Company (“ADSs,” and the ADSs issuable hereunder, the “Warrant ADSs”), with each ADS representing five thousand (5,000) Ordinary Shares (the “ADS Ratio”). The purchase price of one War

Quoin Pharmaceuticals Ltd. Attention: Gordon Dunn Azrieli Center, Round Tower, 30th Floor
Placement Agent Agreement • February 28th, 2023 • Quoin Pharmaceuticals, Ltd. • Surgical & medical instruments & apparatus • New York
AMENDMENT NO. 1 TO Warrant to purchase ordinary shares represented by american depositary shares
Warrant to Purchase Ordinary Shares • February 28th, 2023 • Quoin Pharmaceuticals, Ltd. • Surgical & medical instruments & apparatus

This AMENDMENT NO. 1 TO WARRANT TO PURCHASE ORDINARY SHARES REPRESENTED BY AMERICAN DEPOSITARY SHARES (this “Amendment”) is entered into as of February 24, 2023, by and between Quoin Pharmaceuticals Ltd., a corporation incorporated under the laws of Israel (the “Company”), and [●] (the “Holder”).

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